Who Should Consider Spravato? 

Spravato is indicated for people with Treatment-Resistant Depression (TRD). In the studies that led to Spravato’s FDA approval, the patients had not responded to at least 2 prior antidepressant medications. Spravato was used in conjunction with a traditional antidepressant medication.

Who Should Not Take Spravato?

• You have had an allergic reaction to esketamine or ketamine in the past.

• You have blood vessel (aneurysmal vascular) disease (including in the brain, chest, abdominal aorta, arms and legs).

• You have an abnormal connection between your veins and arteries (arteriovenous malformation).

• You have a history of bleeding in the brain.

• You have uncontrolled high blood pressure.